WASHINGTON—According to an upcoming study appearing in the Journal of the American Society Nephrology (JASN), blood and urine markers can indicate which patients with an abrupt kidney injury following heart surgery will experience progressive kidney problems.
Testing for these markers soon after surgery could help doctors protect the health of patients' kidneys.
Acute kidney injury (AKI), an abrupt or rapid decline in kidney function, is an increasingly prevalent condition. Sometimes AKI arises following heart surgery because the kidneys are deprived of normal blood flow for extended periods of time during the procedure.
In most cases, AKI after heart surgery resolves quickly, but some cases worsen and can seriously affect patients’ health and survival. Until now, doctors have not been able to determine which cases of AKI that develop after heart surgery will worsen.
To see if certain markers in the blood and urine might provide some clues, Chirag Parikh, MD, PhD (Yale University School of Medicine), Jay Koyner, MD (University of Chicago, Pritzker School of Medicine), and their colleagues evaluated the blood and urine of 380 patients who developed AKI after heart surgery.
The investigators found that the presence of certain markers on the day that AKI is diagnosed can indicate structural injury to the kidneys that will likely cause patients to experience progressive problems. High urinary interleukin-18 and a measure called the albumin-to-creatinine ratio increased patients' risk of experiencing persistent AKI by approximately three-fold, while high blood levels of a protein called neutrophil gelatinase-associated lipocalin increased their risk by more than seven-fold.