"Resistant hypertension, which is typical of the aging phenomenon, requires a combination of drugs for blood pressure control," he said. "Currently available medications are not effective to treat resistant hypertensive patients. While my research is focused on aging, the outcomes may very well benefit both adult and older populations who suffer from hypertension."
Citing studies that have linked both a low-sodium diet and exercise to reducing oxidative and inflammatory stress, Asghar is a proponent of moderate, regular exercise and better dietary habits. In addition to further investigating the relationship between high salt and hypertension through his analyses of receptor systems in the kidneys, he also is looking at how exercise and antioxidant or anti-inflammatory therapeutic agents may restore the function of those two key receptors to reduce hypertension.
He believes this exercise research could yield potential therapeutic targets that mimic exercise, which may prove beneficial for those individuals who are unable to exercise due to physical or other disabilities. Asghar and his team's ongoing work could lead to new treatments for millions of hypertensive individuals at risk for stroke, heart failure and a range of other cardiovascular diseases due to high blood pressure, which is a major risk factor for these ailments.