SAN FRANCISCO—Severe acute kidney injuries (AKI's) are becoming more common in the United States, rising 10 percent per year and doubling over the last decade, according to a retrospective study at the University of California, San Francisco (UCSF).
The study, to be published online this week in the Journal of the American Society of Nephrology (JASN), analyzed information from a national database that monitors all causes of hospitalizations and used this data to estimate the total number of AKI's in the United States that were severe enough to require a patient to be placed on dialysis.
The results showed that these injuries, caused by such incidents as major infections, trauma, complications following surgery, and adverse reactions to drugs, increased by 10 percent per year from 2000 to 2009, from 222 to 533 cases per million people. The study also showed that the total number of deaths associated with AKI more than doubled during that time, from 18,000 in 2000 to nearly 39,000 in 2009.
"That was a staggering revelation of how increasingly common and how life-threatening acute kidney injury has become over the past decade in the United States,” said Raymond K. Hsu, MD, a UCSF nephrologist who led the research.
The UCSF team estimated that about 30 percent of the increase can be attributed to commonly known causes, such as the rise in severe infections, ventilator usage, acute heart failure and cardiac catheterizations over the same time period. But doctors do not yet know what else accounts for the rise in acute kidney injury and what hospitals nationwide can do to address the problem, Hsu said.
UCSF is one of the world’s leading centers for kidney disease treatment, research and education, and its Division of Nephrology is nationally ranked among the best programs in the nation by U.S. News & World Report.